Welcome to Add-Aspirin

This website is designed to provide information about the Add-Aspirin Trial, both for people taking part in the trial (participants) and collaborators. Please use the menus at the top of the screen to find out more about the trial.

Add-Aspirin is a large randomised clinical trial, which is taking place in the UK, Republic of Ireland and India. It will recruit 11,000 participants to help find out whether regular aspirin use after treatment for an early stage cancer can prevent the cancer from coming back and preventing deaths.

Congratulations to our top 5 recruiting centres:

  1. University Hospitals Coventry & Warwickshire
  2. Tata Memorial Hospital, Mumbai
  3. Worcestershire Royal Hospital
  4. Royal Marsden Hospitals
  5. Queen Elizabeth Hospital, King's Lynn

*FOR GENERAL AND CLINICAL QUERIES, PLEASE CHECK OUR FAQs*

News

Add-Aspirin Feasibility Data Published

A pre-planned feasibility analysis (based on run-in data from 2253 participants across all tumour cohorts), suggested that aspirin is well-tolerated after radical therapy, with a low burden of toxicity across all tumour groups (13/2253, 0.6% had CTCAE grade 3/4 symptoms). This data has now been published in The Lancet Gastroenterology and Hepatology and can be found here: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(19)30289-4/fulltext

Quick Links

Register a participant

To RANDOMISE a participant from the UK please call +44 (0)20 7670 4777

To RANDOMISE a participant from Republic of Ireland or India only, please use the 'Register a participant' link above to randomise online. Please make sure to press 'Randomise' once logged in to the server.

Unblind a participant in the UK

Unblind a participant in the RoI

Unblind a participant in India

Breast

We aim to recruit 3100 individuals who have had surgery to remove an early stage breast cancer.

CURRENT STATUS:
OPEN 

Detailed eligibility criteria available here 

Top recruiters: Tata Memorial Hospital Mumbai, Western General Hospital, Worcestershire Royal Hospital, Churchill Hospital Oxford  

PARTICIPANTS REGISTERED: 3469
PARTICIPANTS RANDOMISED: 2891

Colon/Rectum

We aim to to recruit 2600 individuals who have had surgery to remove an early stage bowel cancer. 

CURRENT STATUS:
OPEN 

Detailed eligibility criteria available here 

Top recruiters: St James 's University Hospital, Western General Hospital, Bristol Haematology & Oncology Centre, Velindre Hospital

PARTICIPANTS REGISTERED: 2064
PARTICIPANTS RANDOMISED: 1691

Gastro

We aim to recruit 2100 individuals who have had surgery or a combination of chemotherapy and radiotherapy to treat a cancer of the stomach or oesophagus (food pipe).

CURRENT STATUS:
OPEN 

Detailed eligibility criteria available here

Top recruiters: Tata Memorial Hospital Mumbai, Christie Hospital, Cancer Institute (WIA), UHCW, St James's University Hospital

PARTICIPANTS REGISTERED: 434
PARTICIPANTS RANDOMISED: 351

Prostate

We aim to recruit 2120 individuals who have had surgery or radiotherapy to treat an early stage prostate cancer.

CURRENT STATUS:
OPEN 

Detailed eligibility criteria available here

Top recruiters: UHCW,  Darent Valley Hospital, Queen Elizabeth Hospital King's Lynn, University Hospital of Wales

PARTICIPANTS REGISTERED: 1667
PARTICIPANTS RANDOMISED: 1415

the trial is being jointly funded by