A notice for Participants being randomised in Add-Aspirin from 1st April 2023

The Add-Aspirin trial has been studying 2 different doses of aspirin (100mg and 300mg) versus placebo (a dummy tablet) and participants taking part in the trial to date have been randomly assigned one of these two doses or a placebo to take daily for 5 years. The company which manufactures the aspirin used in the trial (Bayer Pharmaceuticals) have recently announced that they will stop producing 300mg aspirin after the end of March 2023. This means that on or after 1st April 2023, new participants joining the trial will receive either 100mg aspirin or placebo only. For every 3 participants randomised to the trial, 2 will receive 100mg aspirin and 1 will receive placebo (which means the chance of being randomised to aspirin remains the same).

The aspirin produced by Bayer has a 5-year shelf life, meaning their last batch of 300mg aspirin will be used until the end of March 2028. Therefore, participants already taking part in the trial will continue on the treatment they were allocated to receive when they joined the trial. This change is an operational decision following the drug manufacturer’s announcement and has no impact on patient safety or the integrity of the trial. The trial oversight committees who monitor the conduct of the trial have approved this change.

The Add-Aspirin team would like to thank you for your continued participation in the Add-Aspirin study.

Contact Details

If you are an individual who is interested in taking part in Add-Aspirin, please talk to your doctor who will be able to consider whether you are suitable for the trial.

For healthcare professionals

Please log into the members area for Add-Aspirin contact details.

Register Interest

For healthcare professionals

If your centre would like to recruit participants to Add-Aspirin, contact us:

Register a participant

From Monday 16th March 2020, to RANDOMISE a participant in the UK please call +44 (0)20 7670 4925, rather than the usual randomisation line.

To RANDOMISE a participant from Republic of Ireland or India only, please use the 'Register a participant' link above to randomise online. Please make sure to press 'Randomise' once logged in to the server.

Unblind a participant in the UK

Unblind a participant in the RoI

Unblind a participant in India