Updated guidance on use of NSAIDs and COVID-19

There have been a number of reports, particularly on social media, suggesting that non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, could worsen symptoms of COVID-19. In response to this, guidance has now been issued by a number of regulatory agencies, including the World Health Organisation, the European Medicines Agency and the UK Commission on Human Medicines. This guidance indicates that there is currently no scientific evidence to support these reports and no reason for patients taking NSAIDs regularly to interrupt their treatment.

Whilst aspirin is classed as a NSAID, the doses given to participants in the trial are not expected to have the anti-inflammatory effects associated with ibuprofen and other similar drugs. Given this, and the guidance above, trial participants are not being recommended to stop their treatment at this time. However, we are constantly reviewing/monitoring the situation and responding to any changes to the advice given.

Participants in the trial are advised to use paracetamol rather than ibuprofen for fever or flu like symptoms (because ibuprofen should not normally be used at the same time as aspirin).

More detailed advice for participants in relation to COVID-19 can be found here.

Contact Details

If you are an individual who is interested in taking part in Add-Aspirin, please talk to your doctor who will be able to consider whether you are suitable for the trial.

For healthcare professionals

Please log into the members area for Add-Aspirin contact details.

Register Interest

For healthcare professionals

If your centre would like to recruit participants to Add-Aspirin, contact us:
mrcctu.add-aspirin@ucl.ac.uk

Register a participant

From Monday 16th March 2020, to RANDOMISE a participant in the UK please call +44 (0)20 7670 4925, rather than the usual randomisation line.

To RANDOMISE a participant from Republic of Ireland or India only, please use the 'Register a participant' link above to randomise online. Please make sure to press 'Randomise' once logged in to the server.

We have been experiencing intermittent issues with the trial websites. In the event of an emergency unblinding outside of office hours (including over the Easter bank holidays), if the usual unblinding links are not working, please telephone +(0)20 7670 4906 or +(0)20 7670 4892 to reach one of the Trial Managers.

Unblind a participant in the UK

Unblind a participant in the RoI

Unblind a participant in India